hrp0095p1-157 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Effect of gonadotropin-releasing hormone agonist monotherapy and combination therapy with growth hormone on final adult height in girls with central precocious puberty

Sang Lee Hae , Young Cho Ah , Suk Shim Young , Sub Lim Jung , Soon Hwang Jin

Objective: This study aimed to compare clinical parameters, including final adult height (FAH), in girls with central precocious puberty treated with gonadotropin-releasing hormone agonists (GnRHa) with and without growth hormone (GH).Methods: This retrospective study reviewed data of 210 girls with precocious puberty who had reached FAH in a long-term trial of GnRHa treatment. The subjects were divided into the GnRHa tr...

hrp0095p2-275 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

A female with 46,XX gonadal dysgenesis presenting with hypergonadotropic hypogonadism and normal height

Ju Choi Young , Jeong Jang Min , Young Cho In , Ho Jung Min , Suh Byung-Kyu

Introduction: Genes on the X chromosome (BMP15, FMR1) and autosomal chromosomes (FOXL2, RSPO1, WNT4) are known to influence ovarian development. 46,XX gonadal dysgenesis is a rare disease caused by chromosomal abnormalities, genetic mutations, and postnatal ovarian damage, leading to premature ovarian failure.Case Report: A 16-year-old female presented with primary amenorrhea and poor breast development. She was born at ...